Mod GRF 1-29 may be a synthetic somatotropin secretagogue from the expansion hormone releasing hormone family. These compounds are supported GHRH, a natural peptide hormone that signals the discharge of GH from the pituitary . GHRH is one among two primary positive regulators of GH secretion in humans, acting along side ghrelin. Both hormones are the themes of in depth drug development. With GHRH, though it are often synthesized as a drug product, it’s not really adequate as a therapeutic agent. it’s too short acting. Mod GRF 1-29 is potentially more viable. it’s a shortened, modified sort of GHRH that’s more immune to enzymatic cleavage. it’s a extended half-life, and may be a stronger agent for increasing serum GH and IGF-1 levels.
Mod GRF 1-29 is nearly just like CJC-1295 in structure. It differs only by the shortage of an attached maleimidoproprionic acid group, also referred to as Drug Affinity Complex (DAC). DAC temporarily binds CJC-1295 to albumin , greatly extending its half-life. this is often why Mod GRF 1-29 is additionally commonly called “CJC-1295 without DAC.” It simply lacks this complex. due to this, Mod GRF 1-29 is far shorter acting. it’s a half-life measured in minutes or hours rather than days. Whereas CJC-1295 are often injected weekly, Mod GRF 1-29 is typically injected several times daily. Otherwise, these two are an equivalent drug… an equivalent active peptide. within the fitness community, Mod GRF 1 -29 is employed for the support of muscle growth and fat loss, also as its potential anti-aging properties.
Much of what else are often said of CJC-1295 should hold true for Mod GRF 1-29. Most basically, this is often to be considered a “selective” GH secretagogue. It displays an excellent deal of specificity for somatotropin release, and is unlikely to significantly alter levels of cortisol, prolactin, LH (luteinizing hormone), or TSH (thyroid stimulating hormone). Likewise, significant spillover side effects concerning these hormones, which are common to several drugs of the GHRP class that mimic ghrelin, are unlikely with Mod GRF 1-29.That isn’t to mention the Mod GRF 1-29 and CJC-1295 are interchangeable. The short acting nature of Mod GRF 1-29 might make it more useful for fostering acute spikes in GH/IGF-1, when used alongside a similarly short acting GHRP
The problem for the bodybuilder or athlete is that it’s a really short half-life of about ten minutes. Despite its short window, it does bind quite effectively to the pituitary receptors. the opposite main down side related to its very short half life is that it’s quickly weakened by blood enzymes within minutes. this is often why a GHRH peptide with a half lifetime of half-hour or longer is desirable (such as GHRP-2, GHRP-6, Hexarelin, or Ipamorelin), since it’ll survive the blood enzyme death and permit it to circulate the body trying to find hormone receptors to bind to.
MOD GRF 1-29 effects
Positive effects of MOD GRF 1-29 include increased lean body mass, reduced fat, increased strength, improved recovery, better sleep, strengthening of the guts , enhancing of the system and increases IGF-1 production.
While the power of MOD GRF to act is brief , it still promotes all of those factors, to not mention it also has the power to extend protein synthesis, promote growth of all internal organs with the exception of the brain and promote and increase in liver glucogenesis.
Despite its tiny half life, MOD GRF’s ability to extend IGF-1 within the blood stream will only further increase the function of the metabolism and therefore the growth of latest cells in muscles, bones and organs. MOD GRF is heavily pushed by HRT clinics and is usually mentioned because the anti-aging peptide since it’s excellent at reversing a number of the consequences of aging in adults.
The fact that doctors can legally prescribe this peptide helps HRT clinics further their legitimacy and also offer a viable and more cost effective solution to prescribing exogenous HGH.
MOD GRF 1-29 administration
Mod GRF 1-29 is provided in vials containing 2 mg of lyophylized powder. The contents should be reconstituted by adding a convenient amount of sterile or bacteriostatic water.
Injection could also be subcutaneous, intramuscular, or intravenous, consistent with personal preference. If desired, peptide solutions from other vials, like a vial of a GHRP product, can also be drawn into an equivalent syringe. This reduces the entire number of injections required.
Recommend dosage is 100 mcg Mod GRF at a time, simultaneous with injection of a GHRP. for max effect, dosing is preferably 3 times per day sometimes of low blood glucose , for instance about half-hour before a meal, but where use is ongoing, a standard use is once per day before sleep.
MOD GRF 1-29 side effects
Common side effects to Mod GRF 1-29 include flushing, warmth, dizziness, and transient hypotension following injection. Other common side effects include sleepiness, headache, diarrhea, nausea, and abdominal pain. Also frequently reported are adverse effects typically related to other sorts of somatotropin therapy, like water retention (edema), joint pain (arthralgias), carpal tunnel syndrome, and numbness or tingling within the extremities. Note that the incidence of GH-related side effects tends to be lower with GHRP therapy as compared to traditional hGFI. this is often because GFI/IGF-1 release is subject to the bounds of endogenous synthesis, and intrinsically the drug is a smaller amount amenable to overdosing.
The subcutaneous administration of this drug may cause redness, itching, pain, or lumps at the location of injection