In men, Clomid also acts as a partial anti-estrogen, and may be used to counter some of the side effects of aromatizable steroid use including gynecomastia and increased water retention. As an anti-estrogenic drug, Clomid may also produce an elevation of follicle-stimulating hormone, and luteinizing hormone levels, which can elevate testosterone production. This effect is especially beneficial at the conclusion of a steroid cycle when endogenous testosterone levels are depressed. Here, Clomid is most often applied in combination with hCG and tamoxifen, in an effort to restore endogenous testosterone production more quickly (see Post-Cycle Therapy). If testosterone levels are not brought back to normal in a short period of time, a significant loss in size and strength may occur. This is due to the fact that without testosterone (or other anabolic/androgenic steroids) to impart an ongoing anabolic message, the catabolic hormone cortisol becomes the dominant force affecting muscle protein synthesis. Often referred to as the post-steroid crash, when not corrected this state of imbalance in the endocrine system can quickly reduce muscle mass levels, diminishing the long-term return on anabolic/androgenic steroid therapy.
Note that the triphenylethylene compounds (toremifene citrate, tamoxifen citrate, clomiphene citrate) tend to be somewhat intrinsically estrogenic in the liver. This means that while they can block estrogenic activity in some areas of the body, they can actually act as estrogens in can block estrogenic activity in some areas of the body, they can actually act as estrogens in this other key area. Estrogenic action in the liver is important in the regulation of serum cholesterol (it tends to support HDL synthesis and LDL reductions). Since steroid-using bodybuilders are already dealing with the negative cardiovascular effects of these drugs, compounding the issue with aromatase inhibitors (which will lower total serum estrogen levels) may not always be the best option. Using a drug that blocks gynecomastia, for example, while at the same time supporting improved cholesterol values, might be much more ideal.
Clomid carries strong anti-estrogen properties that could be used effectively used with anabolic steroid use. Testosterone and many testosterone derived steroids have the ability to convert to estrogen through testosterone’s interaction with the aromatase enzyme. By supplementing with Clomid during anabolic steroid use, the SERM will inhibit the estrogen hormone from binding. This can be very useful in combating gynecomastia as well as water retention.
Clomid, however, is most beneficial to the anabolic steroid user post anabolic steroid use, referred as Post Cycle Therapy (PCT). Clomid has the ability to stimulate enhanced natural testosterone production. This is extremely beneficial to the anabolic steroid user post cycle as natural testosterone levels will be very low due to suppression caused by anabolic steroid use.
Clomid is fairly effective at staving off gynecomastia. It won’t reduce estrogen levels or inhibit the aromatization process, but in many cases, binding to the receptors is enough protection for many men. For the hardcore anabolic steroid users, Clomid is not enough for estrogenic protection. In this case, an Aromatase Inhibitor (AI) such as Anastrozole or Letrozole will be needed.
Using Clomid can also have a positive impact on cholesterol levels. Clomid actually acts as estrogen in the liver, which in turn will promote healthier cholesterol levels. This can be very beneficial to the anabolic steroid user as anabolic steroid use is notorious for promoting unhealthy cholesterol levels.
Clomid is an excellent supplement for Post Cycle Therapy (PCT). When we supplement with anabolic steroids, this will suppress natural testosterone production. The rate of suppression depends on the steroids being used and to a degree the total dosing, but it will generally be substantial. For this reason, most men will always include exogenous testosterone in their steroid cycles. Once steroid use comes to an end natural testosterone levels will be very low, natural testosterone production will begin again on its own, but it will take a significant amount of time for levels to reach their previous high state.
Due to natural testosterone levels being low, most men are encouraged to implement a Post Cycle Therapy (PCT) program. This will stimulate natural testosterone production greatly and shorten the total recovery time. A solid PCT plan will ensure you have enough testosterone for proper bodily function while your levels continue to naturally rise. For this purpose, Clomid is one of the most commonly used PCT medications.
For the anabolic steroid user, standard Clomid doses for on-cycle estrogenic protection will normally be 50mg per day throughout the duration of the cycle. If this doesn’t do the trick, it’s unlikely any amount of Clomid will work. If this does not provide the protection you need, keep in mind many have reported greater success with the SERM Tamoxifen for on-cycle protection. However, you may very well need an Aromatase Inhibitor (AI) such as Anastrazole.
Standard Post Cycle Therapy (PCT) Clomid doses will normally start at 100-150mg per day for 1-2 weeks. From here the dose will drop to 50-100mg per day for 1-2 weeks and finish with 1-2 weeks at 50mg per day. Total Clomid therapy should last 4-6 weeks, so dosing should be based and considered on that total schedule.
Female athletes occasionally use Clomid for the reduction of estrogenicity near the time of a bodybuilding contest. In some instances this may aid in increasing fat loss and muscularity, particularly in female trouble areas such as the hips and thighs. The drug, however, often produces very troubling side effects in pre-menopausal women, and is likewise not in very high demand among this group.
Clomid side effects
Clomid is very well tolerated SERM and anti-estrogen, and this applies to both men and women. However, side effects of Clomid are still possible. Possible side effects of Clomid include headaches, nausea, hot flashes and rarely uterine bleeding and breast discomfort.
The side effects of Clomid are also well noted for including possible visual disturbances. If this occurs, use should be discontinued and alternative medications should be examined. In most all cases, once use is discontinued, vision will shortly return to normal.
Some Clomid users may experience acne, which appears to be most common issue when SERM is used as part of a Post Cycle Therapy (PCT) program. This is not really the SERM that’s causing the issue but rather the high influx of natural testosterone being produced
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