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Long(R3)-IGF-l is a synthetic variant of Insulin-Like Growth Factor-1 (IGF-I), a peptide hormone found naturally in the human body. It is a close derivative of this natural protein. The name “Long R3” actually describes how the original IGF-I protein has been modified. It is made by extending the IGF-I protein with a chain of 13 amino acids, and substituting an arginine at the 3rd position. This new synthetic form of IGF-I seems to retain much of the hormone’s original biological activity. It binds and activates the IGF-I receptor with similar affinity, and imparts a similar anabolic effect. However, it also differs by displaying a significantly longer half-life, and higher resistance to binding proteins, in comparison. As a result, milligram for milligram, Long(R3)-IGF-l is estimated to be approximately 2.5 to 3 times more potent than natural IGF-I. In the fitness community, this substance is most commonly used to support increases in muscle mass.



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IGF-I is a crucial hormone for human development. Its levels are especially high during childhood and adolescence, where it supports linear growth, also because the growth of nearly all body tissues. Serum IGF-I levels decline greatly in adulthood, though remain substantial throughout life. Buy IGF 1 injections online This hormone will still play important roles in metabolism and physiology, including the support of striated muscle mass and strength. IGF-I has several key anabolic/anti-catabolic activities. It supports the synthesis of latest muscle protein, satellite cell activity, and therefore the incorporation of latest nuclei into muscle cells. it’s also noted for reducing the activity of both p27Kip1 and myostatin, which are two powerful inhibitors of muscle growth. As such, IGF-I is considered possessing both strong anabolic and anti-catabolic properties.

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Long(R3)-IGF-l belongs to the expansion Hormone and Related family of medicine .This is because IGF-I levels increase in response to somatotropin administration. This hormone is really liable for most of all of anabolic effect of hGH (somatropin) therapy. Likewise, the 2 have a really direct relationship within the body. However, it’s worth noting that Long(R3)-IGF-l use is probably going to be qualitatively different from that of hGH. While its anabolic effects are presumed to be similar, GH imparts a considerable thermogenic effect that’s not replicated with Long(R3)-IGF-l.To the contrary, the drug can even have lipogenic properties almost like insulin. In some users, it increases the tendency for fat gain, not fat loss. Likewise, Long(R3)-IGF-l would be most closely compared to Increlex (rhIGF-l) therapy instead. Its use is usually characterized by intensified pumps, increased appetite, and moderate increases in lean muscle mass and strength. The stimulation of thermogenesis (fat loss) isn’t one among this drug’s most noteworthy properties.

Long (R3)-IGF-1 Side Effects (Hypoglycemia)
The most common adverse reaction to Long(R3)-IGF-l is hypoglycemia. Signs of mild to moderate hypoglycemia include hunger, drowsiness, blurred vision, depressive mood, dizziness, sweating, palpitation, tremor, restlessness, tingling within the hands, feet, lips, or tongue, lightheadedness, inability to concentrate, headache, sleep disturbances, anxiety, slurred speech, irritability, abnormal behavior, unsteady movement, and personality changes. If any of those warning signs should occur, one should immediately consume a food or drink containing simple sugars like candy or carbohydrate drink. Signs of severe hypoglycemia include disorientation, seizure, and unconsciousness. Severe hypoglycemia can cause death and requires immediate emergency medical attention. Note that in some cases the symptoms of hypoglycemia are often mistaken for drunkenness.

Long(R3)-IGF-l should never be taken before sleep or in above-recommended doses. A meal or snack must be consumed within 20 minutes (before or after) of administration.

Long (R3)-IGF-1 Side Effects (Injection site)
The subcutaneous administration of Long(R3)-IGF-l may cause redness, itching, or bruising at the location of injection. it’s going to also cause a localized increase of fat which can be compounded by the repeated administration at an equivalent site of injection. For these reasons, injection is usually preferred with this substance.

Long (R3)-IGF-1 Side Effects (General)
Other potential adverse reactions to Long(R3)-IGF-l include joint pain, growth of the tonsils, snoring, headache, dizziness, convulsions, vomiting, ear pain, deafness , and hypertrophy of the thymus . Long(R3)-IGF-l can stimulate the expansion of internal organs. Enlargement of the kidney, spleen, and heart were all noted in studies with recombinant IGF-I therapy. Elevations in cholesterol and triglycerides were also observed.The overall relationship between Long(R3)-IGF-I use and cardiac changes remains unclear.Thickening of facial soft tissues is additionally possible, and will be monitored. The abuse of Long(R3)-IGF-l may cause acromegaly, which is characterized by a clear thickening of the bones, most notably the feet, forehead, hands, jaw, and elbows.

Long (R3)-IGF-1 Administration
Long(R3)-IGF-l has not been approved to be used in humans. Prescribing guidelines are unavailable.

When used for physique- or performance-enhancing purposes, Long(R3)-IGF-l is primarily given by injection . A dosage of 20-80 meg daily is most ordinarily used. this is often given in one application, usually earlier within the day. A meal with sufficient carbohydrate content is consumed within 20 minutes of injection to assist reduce the likelihood of hypoglycemia. Long(R3)-IGF-l is usually injected into the muscle which will be trained that day, in an attempt to support site-specific growth. However, the efficacy of this practice remains unclear.

It is generally advised to taper up the dosage of Long(R3)-IGF-l.The user often begins on the low end of the dosage range (20 meg), and increases the quantity by 5-10 meg every 3-4 days, until a desired stable dosage is reached. This practice can help acclimate the user to the consequences of Long(R3)-IGF-l, especially its potential blood-sugar-lowering properties (see: Side Effects).

Cycles of Long(R3)-IGF-l usually last 30-40 days. Beyond this, there’s some concern about desensitization to its anabolic effects. After each cycle, an opportunity of a minimum of 4-6 weeks is typically advised. This drug has not been subject to extensive human testing, however. Likewise, its potential for desensitization has not been clearly characterized.

Long (R3)-IGF-1 Availability
Long(R3)-IGF-l isn’t available as a prescription product. it’s sold exclusively as a compound for research purposes, and “gray market” supplement. Note that the standard of market products are often difficult to assure

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